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Women of childbearing potential have to make use of efficient contraception. As modafinil might scale back the effectiveness of oral contraception various extra strategies of contraception are required (see section four.4 and 4.5). Based on human expertise from a pregnancy registry and spontaneous reporting modafinil is suspected to cause congenital malformations when administered during pregnancy. A variety of tricyclic antidepressants and selective serotonin reuptake inhibitors are largely metabolised by CYP2D6. In patients poor in CYP2D6 (approximately 10 % of a Caucasian population) a normally ancillary metabolic pathway involving CYP2C19 turns into more necessary. As modafinil might inhibit CYP2C19, lower doses of antidepressants could additionally be required in such sufferers. Modafinil might increase its personal metabolism via induction of CYP3A4/5 exercise but the effect is modest and unlikely to have important scientific penalties.
The effects of modafinil on hormonal contraceptives occurs if the hormones are taken by mouth, patch, or implant. Modafinil just isn’t a direct-or indirect-acting dopamine receptor agonist.
Do not cease using your CPAP machine during sleep unless your doctor tells you to. The combination of treatment with CPAP and modafinil may be necessary to best treat your condition. Read all affected person information, treatment guides, and instruction sheets offered to you. You mustn’t use modafinil if you have ever had an allergic reaction or pores and skin rash while taking modafinil or armodafinil . You are encouraged to report unfavorable unwanted effects of prescription drugs to the FDA. Some results of PROVIGIL on the brain are the same as different medicines known as “stimulants”.